ME/CFS: Background
internal_protocol · observational · status: needs_provider_review
Metadata
Author: Axiom Knowledge Base
Citation: Internal reference summary compiled for the Axiom knowledge base (2026).
Embedding: pending
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Summary (generated — provider review required)
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is defined by disabling fatigue, post-exertional malaise, unrefreshing sleep, and cognitive dysfunction. PEM is the cardinal feature and central to pacing-oriented management. Mechanistic hypotheses include mitochondrial, immune, and autonomic dysfunction.
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