Review findings
79 finding(s) · status completed · 2026-06-15 21:44
Review before activation. Approving creates a source-backed record (asset, dosing reference, or evidence claim). Rejected findings are discarded. Findings you have not approved never reach the Clinical Assistant or protocol builder.
Candidate assets
26
- VIPconf 90%pending
3 days for IV acute respiratory failure protocol Repeatable Yes Preparation & Storage Diluent: Sterile 0.9% saline ⚗️ Suggested Bloodwork ( 6 tests) CMP When: Baseline Why: Liver and kidney function CBC When: Baseline Why: General health baseline MSH (melanocyte stimulating hormone) When: Baseline Why: Key CIRS biomarker that VIP helps correct TGF-beta 1 When: Baseline Why: Key CIRS inflammatory marker MMP-9 When: Baseline Why: CIRS inflammation marker VEGF When: Baseline Why: VIP modulates vascular endothelial growth factor 💡 Key Considerations → In the Shoemaker protocol, VIP is the last of 11 treatment steps -- patients must meet specific criteria first (passing VCS, clean ERMI 2 or HERTSMI-2 =10, etc.) → Requires continuous hemodynamic monitoring for IV administration →
- VIPconf 90%pending
Research continues to focus on developing stable VIP analogs and targeted delivery systems to overcome these pharmacological limitations.
- VIPconf 90%pending
VIP: Vasoactive Intestinal Peptide Guide | Peptide Protocol Wiki Skip to main content 🧬 Peptide Protocol Wiki Peptides Side Effects New Learn Directory Tools Blog News About ⌘K ⌘K 🌱 New to Peptides?
- BPC-157conf 90%pending
Peptide Protocol Wiki February 17, 2026 Thymosin Alpha-1 KPV LL-37 + 3 more Guide 14 min read Peptides for Wound Healing: BPC-157, GHK-Cu, TB-500, and the Science of Tissue Repair Evidence-based guide to wound healing peptides including BPC
- GHK-Cuconf 90%pending
Peptide Protocol Wiki February 17, 2026 Thymosin Alpha-1 KPV LL-37 + 3 more Guide 14 min read Peptides for Wound Healing: BPC-157, GHK-Cu, TB-500, and the Science of Tissue Repair Evidence-based guide to wound healing peptides including BPC
- LL-37conf 90%pending
Report an Error Related Articles Research Review 12 min read Immune-Modulating Peptides: Thymosin Alpha-1, KPV, LL-37, and Beyond Comprehensive research review of immune-modulating peptides including thymosin alpha-1, KPV, LL-37, thymalin, VIP, and glutathione.
- KPVconf 90%pending
Report an Error Related Articles Research Review 12 min read Immune-Modulating Peptides: Thymosin Alpha-1, KPV, LL-37, and Beyond Comprehensive research review of immune-modulating peptides including thymosin alpha-1, KPV, LL-37, thymalin, VIP, and glutathione.
- VIPconf 90%pending
Report an Error Related Articles Research Review 12 min read Immune-Modulating Peptides: Thymosin Alpha-1, KPV, LL-37, and Beyond Comprehensive research review of immune-modulating peptides including thymosin alpha-1, KPV, LL-37, thymalin, VIP, and glutathione.
- VIPconf 90%pending
-157, GHK-Cu, TB-500, KPV, and VIP with mechanisms, research findings, and clinical data.
- KPVconf 90%pending
-157, GHK-Cu, TB-500, KPV, and VIP with mechanisms, research findings, and clinical data.
- LL-37conf 90%pending
Peptide Protocol Wiki February 13, 2026 BPC-157 GHK-Cu KPV + 2 more Guide 11 min read 6 Peptides for Gut Health Research Peptides for gut health — BPC-157, KPV, LL-37, VIP, and Glutathione reviewed with mechanisms, evidence levels, and key research findings.
- GHK-Cuconf 90%pending
-157, GHK-Cu, TB-500, KPV, and VIP with mechanisms, research findings, and clinical data.
- BPC-157conf 90%pending
Peptide Protocol Wiki February 13, 2026 BPC-157 GHK-Cu KPV + 2 more Guide 11 min read 6 Peptides for Gut Health Research Peptides for gut health — BPC-157, KPV, LL-37, VIP, and Glutathione reviewed with mechanisms, evidence levels, and key research findings.
- VIPconf 90%pending
PI3K/Akt signaling, which mediates some of VIP's anti-apoptotic and neuroprotective effects; and MAPK/ERK pathway activation, contributing to cell proliferation and differentiation responses.
- VIPconf 90%pending
In the airways, VIP acts as a primary non-adrenergic non-cholinergic (NANC) inhibitory neurotransmitter, producing bronchodilation through analogous cAMP-dependent smooth muscle relaxation.
- VIPconf 90%pending
the side effects of VIP?
- VIPconf 90%pending
VIP is widely distributed throughout the central and peripheral nervous systems, where it functions as a neurotransmitter, neuromodulator, and neurotrophic factor.
- VIPconf 90%pending
Immune Regulation # VIP acts as a potent anti-inflammatory and immunomodulatory agent, providing a critical interface between the nervous and immune systems.
- VIPconf 90%pending
Gut-Brain Axis and Circadian Regulation # VIP plays a critical role in the gut-brain axis, serving as both a neurotransmitter in the enteric nervous system and a signaling molecule in the central regulation of gastrointestinal function.
- VIPconf 90%pending
c PAH have been found to have reduced VIP expression in lung tissue and reduced serum VIP levels compared to healthy controls.
- VIPconf 90%pending
This experience highlighted both the therapeutic potential and the translational challenges of VIP-based therapies.
- VIPconf 90%pending
rch # VIP and its analog stearyl-norleucine-VIP (SNV) have shown neuroprotective efficacy in animal models of Alzheimer disease, Parkinson disease, and cerebral ischemia.
- VIPconf 90%pending
Development of receptor-selective VIP analogs is an active but challenging area of medicinal chemistry research.
- VIPconf 90%pending
Restore access No thanks, continue reading Related Reading Peptide Kisspeptin reproductive hormone regulating peptide Peptide Alprostadil prostaglandin vasodilator Article Peptides for Gut Health Guide How VIP works at the cellular level Overview of VIP benefits and applications Scientific Details Molecular Formula C147H237N43O43S1 Molecular Weight 3326.8 Da CAS Number 37221-79-7 Sequence His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn What is VIP? # Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide first isolated from porcine small intestine by Sami Said and Viktor Mutt in 1970.
- VIPconf 90%pending
Incomplete Understanding of Receptor Dynamics # While the canonical cAMP/PKA signaling downstream of VPAC receptors is well characterized, the roles of non-canonical signaling pathways (PLC/calcium, PI3K/Akt, MAPK/ERK), receptor oligomerization, receptor desensitization, and biased agonism in mediating VIP's diverse tissue-specific effects remain incompletely understood.
- VIPconf 90%pending
tocols VIP side effects profile Kisspeptin research guide Stay current on VIP research We summarize new studies, safety updates, and dosing insights — delivered biweekly.
Candidate dosing
1
- VIPconf 66%pending
nal for pulmonary hypertension and acute respiratory failure 💉 Dosing Amount 50 mcg per spray, 4-8 sprays daily (CIRS/nasal);
dose: 50 mcg · route: nasal · frequency: daily
Candidate safety
11
- VIPconf 60%pending
Consult the detailed side effects profile for full information.
- VIPconf 60%pending
VIP: Vasoactive Intestinal Peptide Guide | Peptide Protocol Wiki Skip to main content 🧬 Peptide Protocol Wiki Peptides Side Effects New Learn Directory Tools Blog News About ⌘K ⌘K 🌱 New to Peptides?
- VIPconf 60%pending
Start the 7-step beginner guide Peptides Side Effects New Directory Learn Tools Blog News About VIP 📋 Overview 🧬 Molecule 🔄 Similar ⚠️ Side Effects 💉 Dosing 🔬 Research 🚨 Risks 👥 Community 📊 Community Data Home Peptides VIP Neuropeptides Immune Support Vascular & Cardiovascular phase2 VIP Also known as: Vasoactive Intestinal Peptide, VIP Peptide, PHM-27 Research compiled by Peptide Protocol Wiki 📅 Updated January 29, 2026 Citations Verified TL;DR Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide belonging to the secretin/glucagon superfamily.
- VIPconf 60%pending
Browse all neuropeptide peptides → Table of Contents 📌 TL;DR • Potent vasodilatory and bronchodilatory effects • Neuroprotective properties in multiple models • Anti-inflammatory and immunomodulatory actions • Roles in circadian rhythm and sleep regulation Community-Reported Side Effects Anecdotal ? 📋 Protocol Quick-Reference CIRS (chronic inflammatory response syndrome) treatment via Shoemaker protocol; investigatio
- VIPconf 60%pending
Neuroprotective Effects # VIP has demonstrated neuroprotective properties across multiple experimental models, including excitotoxicity, oxidative stress, beta-amyloid toxicity, and ischemia-reperfusion injury.
- VIPconf 60%pending
Dose-Limiting Hypotension # The potent vasodilatory activity of VIP, while therapeutically relevant for conditions such as pulmonary hypertension, represents a dose-limiting adverse effect for systemic applications.
- VIPconf 60%pending
tocols VIP side effects profile Kisspeptin research guide Stay current on VIP research We summarize new studies, safety updates, and dosing insights — delivered biweekly.
- VIPconf 60%pending
the side effects of VIP?
- VIPconf 60%pending
Reported side effects of VIP include hypotension, flushing, diarrhea, headache.
- VIPconf 60%pending
Most reported side effects are mild and transient.
- conf 60%pending
Peptide Directory All Peptides Metabolic Anti-Obesity Anti-Aging Immune Hormonal View All Categories Directory Peptide Vendors Analytics Labs Side Effects Database Report a Side Effect Learn Start Here What Are Peptides?
Candidate monitoring
3
- VIPconf 60%pending
IV: continuous monitored infusion 📅 Cycle Duration Ongoing for CIRS protocol (chronic use);
- VIPconf 60%pending
3 days for IV acute respiratory failure protocol Repeatable Yes Preparation & Storage Diluent: Sterile 0.9% saline ⚗️ Suggested Bloodwork ( 6 tests) CMP When: Baseline Why: Liver and kidney function CBC When: Baseline Why: General health baseline MSH (melanocyte stimulating hormone) When: Baseline Why: Key CIRS biomarker that VIP helps correct TGF-beta 1 When: Baseline Why: Key CIRS inflammatory marker MMP-9 When: Baseline Why: CIRS inflammation marker VEGF When: Baseline Why: VIP modulates vascular endothelial growth factor 💡 Key Considerations → In the Shoemaker protocol, VIP is the last of 11 treatment steps -- patients must meet specific criteria first (passing VCS, clean ERMI 2 or HERTSMI-2 =10, etc.) → Requires continuous hemodynamic monitoring for IV administration →
- VIPconf 60%pending
IV use requires clinical setting with hemodynamic monitoring; intranasal use should follow complete Shoemaker protocol for CIRS Subscribe to unlock this content Get weekly peptide research summaries, new study alerts, and protocol updates — free.
Candidate contraindications
1
- VIPconf 70%pending
Contraindication: Avoid in patients with significant hypotension;
Candidate synergies
37
- GHK-Cu + LL-37conf 50%pending
Peptide Protocol Wiki February 17, 2026 Thymosin Alpha-1 KPV LL-37 + 3 more Guide 14 min read Peptides for Wound Healing: BPC-157, GHK-Cu, TB-500, and the Science of Tissue Repair Evidence-based guide to wound healing peptides including BPC
- GHK-Cu + KPVconf 50%pending
Peptide Protocol Wiki February 17, 2026 Thymosin Alpha-1 KPV LL-37 + 3 more Guide 14 min read Peptides for Wound Healing: BPC-157, GHK-Cu, TB-500, and the Science of Tissue Repair Evidence-based guide to wound healing peptides including BPC
- LL-37 + KPVconf 50%pending
Peptide Protocol Wiki February 17, 2026 Thymosin Alpha-1 KPV LL-37 + 3 more Guide 14 min read Peptides for Wound Healing: BPC-157, GHK-Cu, TB-500, and the Science of Tissue Repair Evidence-based guide to wound healing peptides including BPC
- BPC-157 + LL-37conf 50%pending
Peptide Protocol Wiki February 17, 2026 Thymosin Alpha-1 KPV LL-37 + 3 more Guide 14 min read Peptides for Wound Healing: BPC-157, GHK-Cu, TB-500, and the Science of Tissue Repair Evidence-based guide to wound healing peptides including BPC
- BPC-157 + GHK-Cuconf 50%pending
Peptide Protocol Wiki February 17, 2026 Thymosin Alpha-1 KPV LL-37 + 3 more Guide 14 min read Peptides for Wound Healing: BPC-157, GHK-Cu, TB-500, and the Science of Tissue Repair Evidence-based guide to wound healing peptides including BPC
- KPV + VIPconf 50%pending
Report an Error Related Articles Research Review 12 min read Immune-Modulating Peptides: Thymosin Alpha-1, KPV, LL-37, and Beyond Comprehensive research review of immune-modulating peptides including thymosin alpha-1, KPV, LL-37, thymalin, VIP, and glutathione.
- LL-37 + VIPconf 50%pending
Report an Error Related Articles Research Review 12 min read Immune-Modulating Peptides: Thymosin Alpha-1, KPV, LL-37, and Beyond Comprehensive research review of immune-modulating peptides including thymosin alpha-1, KPV, LL-37, thymalin, VIP, and glutathione.
- LL-37 + KPVconf 50%pending
Report an Error Related Articles Research Review 12 min read Immune-Modulating Peptides: Thymosin Alpha-1, KPV, LL-37, and Beyond Comprehensive research review of immune-modulating peptides including thymosin alpha-1, KPV, LL-37, thymalin, VIP, and glutathione.
- GHK-Cu + KPVconf 50%pending
-157, GHK-Cu, TB-500, KPV, and VIP with mechanisms, research findings, and clinical data.
- GHK-Cu + VIPconf 50%pending
-157, GHK-Cu, TB-500, KPV, and VIP with mechanisms, research findings, and clinical data.
- KPV + VIPconf 50%pending
-157, GHK-Cu, TB-500, KPV, and VIP with mechanisms, research findings, and clinical data.
- BPC-157 + GHK-Cuconf 50%pending
Peptide Protocol Wiki February 13, 2026 BPC-157 GHK-Cu KPV + 2 more Guide 11 min read 6 Peptides for Gut Health Research Peptides for gut health — BPC-157, KPV, LL-37, VIP, and Glutathione reviewed with mechanisms, evidence levels, and key research findings.
- BPC-157 + LL-37conf 50%pending
Peptide Protocol Wiki February 13, 2026 BPC-157 GHK-Cu KPV + 2 more Guide 11 min read 6 Peptides for Gut Health Research Peptides for gut health — BPC-157, KPV, LL-37, VIP, and Glutathione reviewed with mechanisms, evidence levels, and key research findings.
- BPC-157 + KPVconf 50%pending
Peptide Protocol Wiki February 13, 2026 BPC-157 GHK-Cu KPV + 2 more Guide 11 min read 6 Peptides for Gut Health Research Peptides for gut health — BPC-157, KPV, LL-37, VIP, and Glutathione reviewed with mechanisms, evidence levels, and key research findings.
- BPC-157 + VIPconf 50%pending
Peptide Protocol Wiki February 13, 2026 BPC-157 GHK-Cu KPV + 2 more Guide 11 min read 6 Peptides for Gut Health Research Peptides for gut health — BPC-157, KPV, LL-37, VIP, and Glutathione reviewed with mechanisms, evidence levels, and key research findings.
- GHK-Cu + LL-37conf 50%pending
Peptide Protocol Wiki February 13, 2026 BPC-157 GHK-Cu KPV + 2 more Guide 11 min read 6 Peptides for Gut Health Research Peptides for gut health — BPC-157, KPV, LL-37, VIP, and Glutathione reviewed with mechanisms, evidence levels, and key research findings.
- GHK-Cu + KPVconf 50%pending
Peptide Protocol Wiki February 13, 2026 BPC-157 GHK-Cu KPV + 2 more Guide 11 min read 6 Peptides for Gut Health Research Peptides for gut health — BPC-157, KPV, LL-37, VIP, and Glutathione reviewed with mechanisms, evidence levels, and key research findings.
- GHK-Cu + VIPconf 50%pending
Peptide Protocol Wiki February 13, 2026 BPC-157 GHK-Cu KPV + 2 more Guide 11 min read 6 Peptides for Gut Health Research Peptides for gut health — BPC-157, KPV, LL-37, VIP, and Glutathione reviewed with mechanisms, evidence levels, and key research findings.
- LL-37 + KPVconf 50%pending
Peptide Protocol Wiki February 13, 2026 BPC-157 GHK-Cu KPV + 2 more Guide 11 min read 6 Peptides for Gut Health Research Peptides for gut health — BPC-157, KPV, LL-37, VIP, and Glutathione reviewed with mechanisms, evidence levels, and key research findings.
- LL-37 + VIPconf 50%pending
Peptide Protocol Wiki February 13, 2026 BPC-157 GHK-Cu KPV + 2 more Guide 11 min read 6 Peptides for Gut Health Research Peptides for gut health — BPC-157, KPV, LL-37, VIP, and Glutathione reviewed with mechanisms, evidence levels, and key research findings.
- KPV + VIPconf 50%pending
Peptide Protocol Wiki February 13, 2026 BPC-157 GHK-Cu KPV + 2 more Guide 11 min read 6 Peptides for Gut Health Research Peptides for gut health — BPC-157, KPV, LL-37, VIP, and Glutathione reviewed with mechanisms, evidence levels, and key research findings.
- BPC-157 + LL-37conf 50%pending
Peptide Protocol Wiki February 10, 2026 BPC-157 KPV LL-37 + 2 more Research Review 12 min read Can Peptides Help with Inflammation?
- BPC-157 + KPVconf 50%pending
Peptide Protocol Wiki February 10, 2026 BPC-157 KPV LL-37 + 2 more Research Review 12 min read Can Peptides Help with Inflammation?
- LL-37 + KPVconf 50%pending
Peptide Protocol Wiki February 10, 2026 BPC-157 KPV LL-37 + 2 more Research Review 12 min read Can Peptides Help with Inflammation?
- BPC-157 + LL-37conf 50%pending
A Research-Based Guide Anti-inflammatory peptides — KPV, BPC-157, LL-37, thymosin alpha-1, VIP, and glutathione — with mechanisms and clinical evidence.
- BPC-157 + KPVconf 50%pending
A Research-Based Guide Anti-inflammatory peptides — KPV, BPC-157, LL-37, thymosin alpha-1, VIP, and glutathione — with mechanisms and clinical evidence.
- BPC-157 + VIPconf 50%pending
A Research-Based Guide Anti-inflammatory peptides — KPV, BPC-157, LL-37, thymosin alpha-1, VIP, and glutathione — with mechanisms and clinical evidence.
- LL-37 + KPVconf 50%pending
A Research-Based Guide Anti-inflammatory peptides — KPV, BPC-157, LL-37, thymosin alpha-1, VIP, and glutathione — with mechanisms and clinical evidence.
- LL-37 + VIPconf 50%pending
A Research-Based Guide Anti-inflammatory peptides — KPV, BPC-157, LL-37, thymosin alpha-1, VIP, and glutathione — with mechanisms and clinical evidence.
- KPV + VIPconf 50%pending
A Research-Based Guide Anti-inflammatory peptides — KPV, BPC-157, LL-37, thymosin alpha-1, VIP, and glutathione — with mechanisms and clinical evidence.
- BPC-157 + GHK-Cuconf 50%pending
Peptide Protocol Wiki February 10, 2026 KPV BPC-157 LL-37 + 3 more You Might Also Like Related content you may find interesting Article research-review Immune-Modulating Peptides: Thymosin Alpha-1, KPV, LL-37, and Beyond Article guide Peptides for Wound Healing: BPC-157, GHK-Cu, TB-500, and the Science of Tissue Repair Article guide 6 Peptides for Gut Health Research Article research-review Can Peptides Help with Inflammation?
- BPC-157 + LL-37conf 50%pending
Peptide Protocol Wiki February 10, 2026 KPV BPC-157 LL-37 + 3 more You Might Also Like Related content you may find interesting Article research-review Immune-Modulating Peptides: Thymosin Alpha-1, KPV, LL-37, and Beyond Article guide Peptides for Wound Healing: BPC-157, GHK-Cu, TB-500, and the Science of Tissue Repair Article guide 6 Peptides for Gut Health Research Article research-review Can Peptides Help with Inflammation?
- BPC-157 + KPVconf 50%pending
Peptide Protocol Wiki February 10, 2026 KPV BPC-157 LL-37 + 3 more You Might Also Like Related content you may find interesting Article research-review Immune-Modulating Peptides: Thymosin Alpha-1, KPV, LL-37, and Beyond Article guide Peptides for Wound Healing: BPC-157, GHK-Cu, TB-500, and the Science of Tissue Repair Article guide 6 Peptides for Gut Health Research Article research-review Can Peptides Help with Inflammation?
- GHK-Cu + LL-37conf 50%pending
Peptide Protocol Wiki February 10, 2026 KPV BPC-157 LL-37 + 3 more You Might Also Like Related content you may find interesting Article research-review Immune-Modulating Peptides: Thymosin Alpha-1, KPV, LL-37, and Beyond Article guide Peptides for Wound Healing: BPC-157, GHK-Cu, TB-500, and the Science of Tissue Repair Article guide 6 Peptides for Gut Health Research Article research-review Can Peptides Help with Inflammation?
- GHK-Cu + KPVconf 50%pending
Peptide Protocol Wiki February 10, 2026 KPV BPC-157 LL-37 + 3 more You Might Also Like Related content you may find interesting Article research-review Immune-Modulating Peptides: Thymosin Alpha-1, KPV, LL-37, and Beyond Article guide Peptides for Wound Healing: BPC-157, GHK-Cu, TB-500, and the Science of Tissue Repair Article guide 6 Peptides for Gut Health Research Article research-review Can Peptides Help with Inflammation?
- LL-37 + KPVconf 50%pending
Peptide Protocol Wiki February 10, 2026 KPV BPC-157 LL-37 + 3 more You Might Also Like Related content you may find interesting Article research-review Immune-Modulating Peptides: Thymosin Alpha-1, KPV, LL-37, and Beyond Article guide Peptides for Wound Healing: BPC-157, GHK-Cu, TB-500, and the Science of Tissue Repair Article guide 6 Peptides for Gut Health Research Article research-review Can Peptides Help with Inflammation?
- BPC-157 + KPVconf 50%pending
Peptide Protocol Wiki February 17, 2026 Thymosin Alpha-1 KPV LL-37 + 3 more Guide 14 min read Peptides for Wound Healing: BPC-157, GHK-Cu, TB-500, and the Science of Tissue Repair Evidence-based guide to wound healing peptides including BPC