Kisspeptin-10
peptideevidence: emerging · v1Description
Kisspeptin-10 is the C-terminal decapeptide of full-length kisspeptin, studied in hypothalamic-pituitary-gonadal axis research models. Lyophilized powder. Reconstitute with bacteriostatic water for in-vitro research. Store at -20°C. Certificate of Analysis attached to this listing.
Mechanism summary
KISS1R (GPR54) Receptor Signaling GnRH Neuron Activation and HPG Axis Control Sex Steroid Feedback Integration Puberty Regulation Therapeutic Applications and Clinical Evidence Kisspeptin in IVF: Oocyte Maturation Trigger Diagnosis of Reproductive Disorders Hypogonadotropic Hypogonadism Research Sexual Function and Psychosexual Effects Evidence Gaps and Limitations Receptor Desensitization Short H [Source: Peptide Protocol Wiki]
How it works
Kisspeptin works near the top of the hormone chain. The brain releases kisspeptin, which turns on GnRH. GnRH then tells the pituitary gland to release LH and FSH. In men, LH tells the testes to make testosterone. FSH helps support sperm production. In women, LH and FSH help control ovulation and follicle growth.
The main receptor is called GPR54, also called KISS1R. A receptor is like a lock on a cell. Kisspeptin is the key that turns that lock. When this signal works, the body can send a stronger LH and FSH message. When this pathway is broken, puberty and fertility signals can fail.
For testosterone research, the key point is simple: kisspeptin does not replace testosterone. It tries to make the body send more LH first. If the testes can respond to LH, testosterone may rise. If the pituitary or testes cannot respond, kisspeptin is unlikely to fix that problem. [Source: Peptide Dosing Protocols]
In plain language
Kisspeptin stimulates the release of hormones that control reproduction, helping to increase testosterone and support fertility.
Reference details
Route(s)
—
Tags
—
Active
yes
Product details · KS10
Price
$79.99
Stock
out of stock
Mol. weight
1302.5 g/mol
Formula
C63H83N17O14
Purity
≥ 99%
CAS #
374675-21-5
Amino sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ (YNWNSFGLRF)
COA: View certificate (batch TET-4896-A) →
Teton Labs product catalog · research-use compound data.
💉 Dosing — 2 references (verbatim from source · not a recommendation)
Dose
9.6 nmol/kg SC (IVF trigger); 1 nmol/kg IV (diagnostic challenge)
Route
subcutaneous
Frequency
Single dose (IVF trigger); single dose (diagnostic)
Duration
Single administration per IVF
Cycle
Repeatable
Reconstitution
Sterile water
Source: Peptide Protocol Wiki (peptideprotocolwiki.com) (publication)Source-backedProvider-reviewed
Dose
Standard: 100-200 mcg · Low: 50-100 mcg
Route
Subcutaneous (SC)
Frequency
Once daily SC
Cycle
8 weeks: 56 doses needed; one vial still leaves margin for losses and schedule adjustments Insulin Syringes (U-100, 0.
Reconstitution
Reconstitute with bacteriostatic water (BAC water) before drawing any dose.
Source: Peptide Dosing Protocols (peptidedosingprotocols.com) (publication)Source-backedProvider-reviewed
Safety, contraindications & monitoring
Contraindications — who should avoid
- Avoid nonstop exposure.
Safety & side effects
- Not FDA-approved. Research-use only.
Monitoring & bloodwork
- Blood test for LH levels.
Clinical evidence
- Human data shows kisspeptin-10 can raise LH in men.
- Longer exposure may also raise testosterone, but that depends on the testes being able to respond to LH.
Source-backedProvider-reviewedApproved findings drawn from your sources — decision support, not medical advice.
Provider-only reference. This page does not constitute medical advice, a recommendation, or dosing guidance.