Selank
peptideevidence: emerging · v1.0.0Description
Selank is a synthetic heptapeptide analog of the immunomodulatory peptide tuftsin, studied in anxiolytic and neurotrophic research models. Lyophilized powder. Reconstitute with bacteriostatic water for in-vitro research. Store at -20°C. Certificate of Analysis attached to this listing.
Mechanism summary
Modulation of neuropeptide and immune signaling.
How it works
Selank works through several brain pathways at once. That is why it can calm anxiety while still leaving thinking sharp, instead of dulling the mind the way many anti-anxiety drugs do.
GABA System GABA is the brain's main slow-down signal. When GABA is active, overexcited brain cells settle. Selank changes how GABA's docking sites work in a way that looks similar to how benzodiazepines act, but without the same sedation or dependence pattern.
Serotonin and Dopamine Selank affects how the brain handles serotonin, dopamine, and norepinephrine. Serotonin shifts help mood. Dopamine and norepinephrine shifts help focus, motivation, and learning.
BDNF (Brain Growth Signal) BDNF is a protein that helps brain cells grow and connect. Intranasal Selank quickly raises BDNF levels in the hippocampus in animal studies. The hippocampus is the brain region most tied to memory.
Enkephalin Stabilization Enkephalins are the body's natural calming molecules, similar in family to endorphins. Selank slows the enzymes that break enkephalins down, so they stay active in the bloodstream longer.
Immune Signaling Selank is built from tuftsin, an immune-related molecule the body makes on its own. So Selank also nudges immune signals like IL-6 and the Th1/Th2 balance. In one Russian study of anxiety patients, those immune markers shifted across a 14-day course. [Source: Peptide Dosing Protocols]
In plain language
Selank helps reduce anxiety and improve focus by interacting with brain chemicals and pathways, including GABA, serotonin, and dopamine.
Reference details
Route(s)
intranasal
Tags
neuroinflammation, sleep
Active
yes
Product details · SK10
Price
$39.99
Stock
low stock
Mol. weight
751.9 g/mol
Formula
C33H57N11O9
Purity
≥ 99%
CAS #
129954-34-3
Amino sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
COA: View certificate (batch TET-4904-A) →
Teton Labs product catalog · research-use compound data.
💉 Dosing — 3 references (verbatim from source · not a recommendation)
Dose
250-500 mcg intranasally daily (or 0.15% solution per protocol)
Route
intranasal
Frequency
once or twice daily
Duration
10-14 day cycles
Cycle
Repeat cycles per provider direction
Reconstitution
Compounded intranasal solution - no reconstitution required
Vial
Compounded intranasal solution/spray
Source: Practitioner Peptide Dosing Reference (commonly published ranges) — Compiled practitioner reference (internal_protocol)Source-backedProvider-reviewed
Dose
300-600 mcg per dose intranasal; 200-400 mcg per dose subcutaneous
Route
subcutaneous or intranasal or oral
Frequency
2-3 times daily (intranasal); once daily (SC, 5 days per week)
Duration
30 days on, 30 days off; approximately 6
Source: Peptide Protocol Wiki (peptideprotocolwiki.com) (publication)Source-backedProvider-reviewed
Dose
Standard: 250-500 mcg per day · Low: 250 mcg · High: 500 mcg
Route
Subcutaneous injection (SubQ) or intranasal nasal spray
Frequency
once daily for SubQ; 14-21 days for intranasal
Duration
4 weeks for SubQ; 14-21 days for intranasal
Cycle
4 weeks on, 4 weeks off for SubQ; 1-3 weeks off for intranasal
Reconstitution
3 mL, 6 mL, or 10 mL per 30 mg vial
Source: Peptide Dosing Protocols (peptidedosingprotocols.com) (publication)Source-backedProvider-reviewed
Safety, contraindications & monitoring
Contraindications — who should avoid
- Not for unsupervised human use.
- Not FDA-approved in the United States.
Safety & side effects
- Selank has a mild safety profile.
- Lower starting doses help find the dose where the calming effect shows up without extra side effects.
Monitoring & bloodwork
- CBC at baseline and week 4
Clinical evidence
- Russian clinical protocols use a 14-21 day course at 600-2,700 mcg per day, split into 2 or 3 sprays. · Russian clinical reference protocols
- Dr. William Seeds has documented injectable Selank doses of 100-300 mcg per day as appropriate and well tolerated for most subjects. · Seeds/2026
Source-backedProvider-reviewedApproved findings drawn from your sources — decision support, not medical advice.
Provider-only reference. This page does not constitute medical advice, a recommendation, or dosing guidance.