DSIP
peptideevidence: emerging · v1.0.0Description
DSIP (delta sleep-inducing peptide) is a nonapeptide studied in sleep-architecture research models. Lyophilized powder. Reconstitute with bacteriostatic water for in-vitro research. Store at -20°C. Certificate of Analysis attached to this listing.
Mechanism summary
Sleep-related neuropeptide signaling.
How it works
DSIP is a small naturally occurring nonapeptide with the amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu and a molecular weight of about 849 daltons. Its name comes from the early observation that infusion produced delta-wave (slow-wave) EEG activity in rabbits. Despite decades of work, the precise receptor and mechanism are still not fully established. Reviews describe possible interactions with NMDA receptors, alpha-adrenergic signaling, opioid receptors, and the hypothalamic-pituitary-adrenal axis. DSIP-like material has been found in the hypothalamus, limbic system, pituitary, and gut.
Older work characterized DSIP as a sleep-modulating peptide rather than a sedative, with a U-shaped activity curve where small doses or short infusions produced the strongest effect. [Source: Peptide Dosing Protocols]
In plain language
DSIP is a peptide that helps modulate sleep patterns rather than acting as a sedative, and it may interact with various receptors in the brain.
Reference details
Route(s)
subcutaneous
Tags
sleep
Active
yes
Product details · DS10
Price
$49.99
Stock
low stock
Mol. weight
848.8 g/mol
Formula
C35H48N10O15
Purity
≥ 99%
CAS #
62568-57-4
Amino sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE)
COA: View certificate (batch TET-4891-A) →
Teton Labs product catalog · research-use compound data.
💉 Dosing — 2 references (verbatim from source · not a recommendation)
Dose
100-300 mcg subcutaneous; 25 nmol/kg IV (~1.5 mg for 70 kg person)
Route
subcutaneous or intranasal
Frequency
Once daily before bed; or every 2-3 days
Duration
have not been established.
Reconstitution
Bacteriostatic water
Source: Peptide Protocol Wiki (peptideprotocolwiki.com) (publication)Source-backedProvider-reviewed
Dose
Standard: 100-200 mcg · Low: 100 mcg · High: 300 mcg
Route
SubQ
Frequency
once daily
Duration
5-7 nights
Cycle
short course
Reconstitution
2.0 mL bacteriostatic water
Source: Peptide Dosing Protocols (peptidedosingprotocols.com) (publication)Source-backedProvider-reviewed
Safety, contraindications & monitoring
Contraindications — who should avoid
- Untreated obstructive sleep apnea: any sleep-modulating compound deserves clinical oversight.
- Pregnancy and lactation: not studied; should be avoided.
- Children and adolescents: no human pediatric data.
- Active substance dependence: published trials in opioid- and alcohol-withdrawal contexts were small and used clinical settings, not self-directed protocols.
- Adrenal or thyroid disease: DSIP can interact with HPA-axis signaling; clinical oversight is warranted.
- Anyone on sedating medications: combined effects are not well characterized.
Safety & side effects
- Mild transient headache or nausea reported in some early human studies.
- Theoretical immunogenicity flagged by FDA in the Category 2 listing.
- Possible interaction with HPA-axis hormones; not characterized in modern trials.
- Quality-control risk for any research-use peptide (purity, contamination, mislabeling).
- Possible morning sluggishness or vivid dream effects described in research write-ups.
Monitoring & bloodwork
- Time to fall asleep.
- Number of awakenings.
- Subjective sleep quality.
- Morning alertness.
- Any side effects.
Clinical evidence
- Older human trials and reviews report that DSIP appeared well tolerated at the doses tested. · null
- Subjective sleep changes are most often reported within the first or second night of dosing. · null
- Short-course trials measured sleep architecture and daytime alertness across 5-7 nights. · null
Source-backedProvider-reviewedApproved findings drawn from your sources — decision support, not medical advice.
Provider-only reference. This page does not constitute medical advice, a recommendation, or dosing guidance.