Epitalon
peptideevidence: theoretical · v1.0.0Description
Epithalon (epitalon) is a synthetic tetrapeptide studied in telomere and pineal-axis research models. Lyophilized powder. Reconstitute with bacteriostatic water for in-vitro research. Store at -20°C. Certificate of Analysis attached to this listing.
Mechanism summary
Telomerase/circadian-related signaling (largely preclinical).
How it works
Epitalon, also known as epithalon or AEDG, is a synthetic peptide composed of four amino acids: Alanine, Glutamic acid, Aspartic acid, and Glycine. It is primarily studied for its potential effects on aging, particularly in relation to telomeres and circadian rhythms. Telomeres are protective caps at the ends of chromosomes that shorten with each cell division, and their length is associated with cellular aging. Research indicates that epitalon may enhance telomerase activity, an enzyme that can extend the lifespan of cells by maintaining telomere length. In a study by Khavinson et al. (2003), it was reported that epitalon raised telomerase activity and extended the dividing lifespan of human fibroblasts beyond the usual limit.
Additionally, epitalon is linked to the regulation of the body's circadian rhythm, which controls sleep patterns and melatonin production. The timing of epitalon administration is often aligned with natural melatonin rhythms, with many protocols recommending evening dosing. This connection to melatonin may explain some of the peptide's effects on sleep and overall well-being.
Despite the promising mechanisms, it is important to note that there is no large, blinded human trial that has tested a specific epitalon injection dose against a placebo for telomere length. The dosing patterns reported in the literature are derived from older Russian research programs and community protocols rather than modern clinical trials. Therefore, while the mechanisms of action are supported by some studies, the clinical efficacy in humans remains to be conclusively established. [Source: Peptide Dosing Protocols]
In plain language
Epitalon is a synthetic peptide that may help maintain telomere length and regulate sleep patterns by enhancing telomerase activity and aligning with melatonin rhythms.
Reference details
Route(s)
subcutaneous
Tags
repair, sleep
Active
yes
Product details · ET50
Price
$99.99
Stock
low stock
Mol. weight
390.3 g/mol
Formula
C14H22N4O9
Purity
≥ 99%
CAS #
307297-39-8
Amino sequence: Ala-Glu-Asp-Gly (AEDG)
COA: View certificate (batch TET-4889-A) →
Teton Labs product catalog · research-use compound data.
💉 Dosing — 2 references (verbatim from source · not a recommendation)
Dose
5-10 mg per day
Route
subcutaneous or oral
Frequency
Once daily
Reconstitution
Bacteriostatic water
Source: Peptide Protocol Wiki (peptideprotocolwiki.com) (publication)Source-backedProvider-reviewed
Dose
Standard: 5 mg/day · High: 10 mg/day
Route
SubQ
Frequency
2-3 times per year
Duration
20 days
Cycle
short cycle
Reconstitution
Add 2.0 mL BAC water to a 10 mg vial.
Source: Peptide Dosing Protocols (peptidedosingprotocols.com) (publication)Source-backedProvider-reviewed
Safety, contraindications & monitoring
Contraindications — who should avoid
- Anyone who is pregnant or breastfeeding.
- Anyone who cannot verify product quality with a current certificate of analysis (COA).
- Anyone on prescription medications without first talking to a qualified clinician.
- Anyone with an active cancer or a recent cancer history.
Safety & side effects
- Occasional reports of headache or temporary changes in sleep.
- Mild drowsiness, especially with evening dosing.
- Injection-site reactions: redness, soreness, or a small bump where the needle went in.
Monitoring & bloodwork
- Some longevity researchers track telomere length or biological-age panels.
- No standard required lab markers for epitalon.
Clinical evidence
- A 2025 independent study reported telomere lengthening in human cell lines. · Biogerontology, 2025
- Epitalon raised telomerase activity and extended the dividing lifespan of human fibroblasts past the usual limit. · Khavinson et al., 2003
- A long-running, non-blinded program in elderly subjects reported lower mortality with epithalamin. · Khavinson, 2003
- A 12-year study reported 28% lower mortality and 2-fold lower cardiovascular mortality in treated elderly patients. · Korkushko et al., 2006
- Improved circadian melatonin rhythm in elderly people given the pineal extract. · Korkushko et al., 2004
Source-backedProvider-reviewedApproved findings drawn from your sources — decision support, not medical advice.
Provider-only reference. This page does not constitute medical advice, a recommendation, or dosing guidance.