SS-31

SS-31 (elamipretide) is a mitochondria-targeting tetrapeptide studied in cardiolipin-protection and mitochondrial-bioenergetics research models. Lyophilized powder. Reconstitute with bacteriostatic water for in-vitro research. Store at -20°C. Certificate of Analysis attached to this listing.

Cardiolipin interaction; mitochondrial function support.

SS-31, also known as elamipretide, is a synthetic four-amino-acid peptide that operates by binding to cardiolipin, a phospholipid located in the inner mitochondrial membrane. This binding stabilizes the structural scaffold of the mitochondria, which is essential for the organization of the energy-producing machinery within the cell. By stabilizing cardiolipin under stress conditions, SS-31 helps maintain mitochondrial function and integrity, particularly in the context of diseases characterized by mitochondrial dysfunction.

The strongest evidence for the efficacy of SS-31 comes from the Phase 2/3 clinical trial known as TAZPOWER, which focused on patients with Barth syndrome. This trial demonstrated that SS-31 could improve muscle strength in this specific patient population, leading to its FDA approval as Forzinity in September 2025. The mechanism of action of SS-31 is distinct from other mitochondrial-targeted compounds, such as MOTS-c, which is a signaling peptide that influences energy metabolism through AMPK pathway signaling. In contrast, SS-31 acts primarily as a structural stabilizer within the mitochondrial membrane, making it a unique therapeutic option for conditions like Barth syndrome that involve mitochondrial dysfunction. [Source: Peptide Dosing Protocols]

Amino sequence: D-Arg-Dmt-Lys-Phe-NH₂ (elamipretide)

COA: View certificate (batch TET-4765-B) →

Teton Labs product catalog · research-use compound data.