Sermorelin Acetate
peptideevidence: emerging · v1Description
Sermorelin is a synthetic 29-amino-acid analog of growth-hormone-releasing hormone (GHRH) studied in growth-hormone axis research. Lyophilized powder. Reconstitute with bacteriostatic water for in-vitro research. Store at -20°C. Certificate of Analysis attached to this listing.
Mechanism summary
Sermorelin is a small peptide that copies the first 29 amino acids of the body's natural growth hormone-releasing hormone (GHRH). It fits the pituitary gland's GHRH receptor, triggering a normal growth hormone (GH) pulse. [Source: Peptide Dosing Protocols]
How it works
Sermorelin works by talking to the pituitary gland, a small gland at the base of the brain that makes growth hormone (GH). The pituitary normally listens for a signal from the brain called GHRH (growth hormone-releasing hormone). When GHRH shows up, the pituitary releases a burst of GH.
Sermorelin is a short copy of GHRH. The natural hormone is 44 amino acids long. Sermorelin uses only the first 29. Despite being shorter, the 29-amino-acid version still fits the GHRH receptor and still triggers a GH pulse. That is the main mechanism.
The body has a natural off switch hormone called somatostatin. When GH levels climb too high, somatostatin steps in and quiets the pituitary back down. Because sermorelin works through the body's own GHRH pathway, this off switch stays active. GH levels rise in natural pulses rather than staying flat and elevated.
This is the key difference from direct GH injections. With direct GH, the dose you inject is the dose you get - the off switch is bypassed. With sermorelin, the brake is still on, so the body protects itself from very high GH levels even at higher sermorelin doses.
Healthy growth hormone in the body is pulsatile - it rises and falls in waves, with the biggest waves during early sleep. Sermorelin's short half-life (11-12 minutes) actually fits this pattern well. It nudges the pituitary into making a pulse, then clears out fast, leaving the body's own rhythm in place.
Receptor: GHRH receptor on pituitary somatotroph cells. Trigger: cAMP signaling inside the cell, which causes GH release. Brake: Somatostatin feedback keeps GH from climbing too high. Why nightly: Sermorelin clears in minutes, but the GH pulse it triggers fits the natural early-night surge. [Source: Peptide Dosing Protocols]
In plain language
Sermorelin stimulates the pituitary gland to release growth hormone by mimicking a natural hormone, while also ensuring that the body regulates the amount of growth hormone released.
Reference details
Route(s)
—
Tags
—
Active
yes
Product details · SMO10
Price
$69.99
Stock
low stock
Mol. weight
3357.9 g/mol
Formula
C149H246N44O42S
Purity
≥ 99%
CAS #
86168-78-7
Amino sequence: GRF(1-29)-NH₂ (sermorelin)
Teton Labs product catalog · research-use compound data.
💉 Dosing — 2 references (verbatim from source · not a recommendation)
Dose
200-300 mcg
Route
subcutaneous or oral
Frequency
Once daily at bedtime, 5 nights per week
Duration
3-6 months,
Reconstitution
Bacteriostatic water
Source: Peptide Protocol Wiki (peptideprotocolwiki.com) (publication)Source-backedProvider-reviewed
Dose
Standard: 200-300 mcg · Low: 100 mcg · High: 400-500 mcg
Route
subcutaneous injection
Frequency
nightly
Duration
3-6 months
Cycle
Cycle length Planning note 4 weeks 1 vial 28 nights of 200 mcg from one vial.
Reconstitution
3 mL bacteriostatic (BAC) water in a 10 mg vial gives 3 units per 100 mcg on a U-100 insulin syringe.
Source: Peptide Dosing Protocols (peptidedosingprotocols.com) (publication)Source-backedProvider-reviewed
Safety, contraindications & monitoring
Contraindications — who should avoid
- Individuals with untreated hypothyroidism should avoid it.
Safety & side effects
- Common side effects may include injection-site reactions and sleep changes.
Monitoring & bloodwork
- Baseline labs (IGF-1 plus a thyroid panel), repeat at week 6, and again at week 12.
Clinical evidence
- About 6.5% of FDA-era trial participants developed hypothyroidism. · null
Source-backedProvider-reviewedApproved findings drawn from your sources — decision support, not medical advice.
Provider-only reference. This page does not constitute medical advice, a recommendation, or dosing guidance.