Glutathione
supplementevidence: emerging · v1Description
Glutathione is a tripeptide antioxidant central to cellular redox biology research. Lyophilized powder. Reconstitute with sterile water or BAC water for in-vitro research. Store at -20°C. Certificate of Analysis attached to this listing.
Mechanism summary
Glutathione is your cells' main cleanup molecule. It grabs onto unstable molecules called free radicals and neutralizes them before they damage cell parts. It also helps the liver tag and remove certain toxins so they can leave the body. Glutathione donates an electron from its cysteine sulfur group to neutralize reactive oxygen species. For skin specifically, glutathione blocks an enzyme called tyrosinase and nudges pigment cells toward making lighter pheomelanin instead of darker eumelanin. [Source: Peptide Dosing Protocols]
How it works
How Glutathione Works In plain English: glutathione is your cells' main cleanup molecule. It grabs onto unstable molecules called free radicals and neutralizes them before they damage cell parts. It also helps the liver tag and remove certain toxins so they can leave the body.
The technical version: glutathione donates an electron from its cysteine sulfur group to neutralize reactive oxygen species. In doing so it becomes oxidized (GSSG), then an enzyme called glutathione reductase recycles it back to the active reduced form (GSH). The ratio of GSH to GSSG is a common lab marker of how much oxidative stress a cell is under.
For skin specifically, glutathione blocks an enzyme called tyrosinase and nudges pigment cells toward making lighter pheomelanin instead of darker eumelanin. That is the mechanism behind the skin-lightening research — and also why regulators worry that lightening could reduce the skin's natural UV protection over time.
One well-established clinical fact anchors all of this: when someone overdoses on acetaminophen (Tylenol), the liver burns through its glutathione detoxifying the drug. The antidote, N-acetylcysteine (NAC), works by refilling the cysteine your liver needs to rebuild glutathione. That is real, FDA-recognized pharmacology, and it explains why cysteine supply is the rate-limiting step for making glutathione. [Source: Peptide Dosing Protocols]
In plain language
Glutathione helps clean up harmful free radicals in cells and assists the liver in detoxifying substances. It also plays a role in skin lightening by affecting pigment production.
Reference details
Route(s)
—
Tags
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Active
yes
Product details · GTT
Price
$89.99
Stock
in stock
Mol. weight
307.3 g/mol
Formula
C10H17N3O6S
Purity
≥ 99%
CAS #
70-18-8
Amino sequence: γ-Glu-Cys-Gly (reduced glutathione)
Teton Labs product catalog · research-use compound data.
💉 Dosing — 2 references (verbatim from source · not a recommendation)
Dose
200-600 mg per injection (IM/SC); 600-1400 mg per session (IV push); 500-1000 mg daily (oral)
Route
subcutaneous or intranasal or oral or topical or intramuscular
Frequency
1-3 times per week (injectable); daily (oral)
Duration
Key limitations / notes
Source: Peptide Protocol Wiki (peptideprotocolwiki.com) (publication)Source-backedProvider-reviewed
Dose
Standard: 250-1,000 mg/day · Low: 250 mg/day · High: 1,000 mg/day
Route
Oral
Frequency
daily
Duration
4 weeks - 6 months
Cycle
4 weeks or longer to appear and faded after stopping.
Reconstitution
reconstitution and supplies for injectable use, side effects, and where the evidence stops.
Source: Peptide Dosing Protocols (peptidedosingprotocols.com) (publication)Source-backedProvider-reviewed
Safety, contraindications & monitoring
Contraindications — who should avoid
- People with asthma.
- Pregnant or breastfeeding people: safety has not been established in trials; avoid unless a clinician advises otherwise.
- Anyone considering IV/injectable glutathione: highest risk group.
- People on medications metabolized by the liver.
Safety & side effects
- IV is not FDA-approved for skin lightening and carries real safety risks.
- Inhaled/nebulized glutathione has triggered bronchospasm in some reports.
Monitoring & bloodwork
- Discuss interactions with a clinician.
Clinical evidence
- IV and injectable glutathione for skin lightening is not FDA-approved. · US FDA, June 2019
- Studies disagree on whether standard oral glutathione even reaches your bloodstream in a useful way. · Richie et al., 2015
- Intranasal glutathione looked safe and tolerable, but it did not clearly outperform a saline spray over three months. · Mischley et al., 2017
Source-backedProvider-reviewedApproved findings drawn from your sources — decision support, not medical advice.
Provider-only reference. This page does not constitute medical advice, a recommendation, or dosing guidance.