MOTS-c

MOTS-c is a mitochondrial-derived peptide studied in cellular metabolism, insulin sensitivity, and exercise-physiology research. Lyophilized powder. Reconstitute with bacteriostatic water for in-vitro research. Store at -20°C. Certificate of Analysis attached to this listing.

Mitochondrial and metabolic signaling.

MOTS-c is encoded by mitochondrial DNA, distinguishing it from the DNA found in the cell nucleus. This places it within a unique category known as mitochondria-derived peptides. The synthesis of MOTS-c increases during periods of physical stress and exercise, while its levels tend to decline with age. The primary mechanism through which MOTS-c exerts its effects is through the activation of AMP-activated protein kinase (AMPK), an enzyme that functions as a critical energy switch within cells. When AMPK is activated, it prompts cells to uptake more glucose, enhances fat oxidation, and promotes the biogenesis of mitochondria over time.

The activation of AMPK by MOTS-c has been documented in a study by Lee and colleagues (2015, Cell Metabolism), which utilized mouse and cell models to illustrate the metabolic changes associated with MOTS-c. The authors noted that the metabolic profile induced by MOTS-c bore similarities to that of the diabetes medication metformin, although they refrained from suggesting that the two are interchangeable. Further research by Reynolds and colleagues (2021, Nature Communications) demonstrated that MOTS-c improved running capacity across various age groups in mice, leading some sources to label it as an exercise-mimetic. However, it is important to note that no human randomized trial has yet confirmed this effect on running capacity.

MOTS-c has been investigated for its potential applications in metabolic health, exercise performance, and aging, but none of these uses have received FDA approval. The peptide is often studied in the context of glucose handling and insulin sensitivity, exercise capacity, bone metabolism, and inflammation. Notably, the research surrounding MOTS-c is still in its early stages, and while the mechanistic evidence is robust in animal studies, the translation to human applications remains limited. [Source: Peptide Dosing Protocols]

Amino sequence: MRWQEMGYIFYPRKLR

COA: View certificate (batch TET-4902-A) →

Teton Labs product catalog · research-use compound data.